Zopiclone (Imovane) is indicated for the short-term treatment and symptomatic reduction of insomnia characterised by issue in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone ought to often not exceed 7-10 consecutive days. Use for greater than 2-3 consecutive weeks requires complete re-evaluation of the affected person. Prescriptions for zopiclone should be written for short-term use (7-10 days) and it should not be prescribed in quantities exceeding a 1-month supply.
The use of hypnotics must be restricted for insomnia the place disturbed sleep leads to impaired daytime functioning.
Imovane ought to only be taken when you are ready to get a full evening’s sleep (7 to 8 hours) before you need to be energetic again.
The normal adult dose of zopiclone is one pill just earlier than you go to mattress.
This medicine must be taken in a single consumption and not readministered during the same night time.
If you would possibly be over 65 years of age the dose is half a tablet taken just earlier than you go to mattress.
If you’ve a liver or kidney drawback, the standard really helpful dose is half a pill taken simply earlier than you go to mattress.
Overdose by zopiclone drugs is normally manifested by various degrees of central nervous system despair ranging from drowsiness to coma in accordance with the amount ingested. In delicate instances, symptoms embody drowsiness, confusion, and lethargy; in additional severe cases, signs may embody ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory melancholy, and coma. Overdose should not be life threatening unless combined with other CNS depressants, together with alcohol. Other danger elements, such because the presence of concomitant illness and the debilitated state of the patient, may contribute to the severity of signs and very rarely can end result in deadly end result.
In voluntary or accidental cases of zopiclone overdosage involving doses up to 340 mg, the principal results reported were extended sleep, drowsiness, lethargy and ataxia.
Symptomatic and supportive remedy in adequate scientific environment is really helpful, attention ought to be paid to respiratory and cardiovascular capabilities. Gastric lavage or activated charcoal is only useful when carried out soon after ingestion.
Hemodialysis is of no worth because of the massive volume of distribution of zopiclone. Flumazenil may be a useful antidote; however, flumazenil administration might contribute to the looks of neurological symptoms (agitation, nervousness, convulsionsand emotional lability). Intravenous fluids ought to be administered as needed.